They say that it doesn't really matter. I got the 3 out of 4 special though! My first daughter had none. My second daughter had a lip hemangioma requiring treatment. Then I had twin girls. One had a big one on her hand, the other a small one on her arm. Neither needed any treatment. However, I asked her doctor...a well known specialist and he said it the those at highest risks were white skinned, preemies and girls...and so I should stop having those!!! ha ha!!! He thought it was more likely that all my children are in those categories rather than it running in the family. So, I guess the answer is technically no....but for us, I guess we just got lucky!